Thermo Fisher Scientific RPL7A Monoclonal Antibody (OTI3C5), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
This gene encodes a ribosomal protein that is a component of the 60S subunit and belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to DNA response elements.
This gene is included in the surfeit gene cluster, a group of tightly linked genes that do not share sequence similarity. It is co-transcribed with small nucleolar RNA genes (U24, U36a, U36b, U36c) located in its introns.
The gene can rearrange with the trk proto-oncogene to form the chimeric oncogene trk-2h, encoding an oncoprotein consisting of the N-terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk.
As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes of this gene are dispersed throughout the genome.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.