Thermo Fisher Scientific Rad18 Polyclonal Antibody
인간 RAD18 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 1 mg/mL 농도의 액상 형태로 제공. 4°C 보관, 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human E3 ubiquitin-protein ligase RAD18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Human Rad18 (hRad18) is a homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions, particularly in gap-filling of the daughter strand during replication of damaged DNA. The Rad6–Rad18 interaction is critical at an early step of lesion bypass. In vivo, Rad18 forms a tight complex with Rad6 through a conserved ring-finger motif. The Rad18–Rad6 complex binds to damaged DNA sites via the single-stranded DNA binding property of Rad18, followed by degradation of stalled replication components through the ubiquitin-conjugating activity of Rad6.
The human RAD18 gene maps to chromosome 3p24–25, a region often deleted in lung, breast, ovary, and testis cancers. It encodes a 495-amino acid protein with a predicted molecular weight of 56 kDa and is ubiquitously expressed in various human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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