Thermo Fisher Scientific FANCD2 Polyclonal Antibody
FANCD2 단백질 검출용 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드 면역원 기반, Affinity chromatography로 정제됨. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FANCD2 (Accession Q9BXW9), corresponding to amino acid residues D693–R743 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851973 |
Product Specific Information
This antibody detects endogenous levels of total FANCD2.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for the maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis and is involved in the repair of DNA double-stranded breaks via homologous recombination and single-stranded annealing. FANCD2 is necessary for targeting and stabilizing BLM to abnormal non-centromeric structures induced by replicative stress and promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene cause Fanconi anemia complementation group D2, a disorder affecting all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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