Thermo Fisher Scientific C1orf51 Polyclonal Antibody
C1orf51 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간·생쥐·랫트 반응성. WB 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 장기 보관 시 -20°C에서 안정적. 생체 시계 관련 전사 억제 인자 연구에 적합.
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Thermo Fisher Scientific C1orf51 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human C1orf51. Recombinant protein control fragment (Product #RP-94333) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638942 |
Product Specific Information
Immunogen sequence:
NTQGCTTEGD LLFAQKCKEL QGFIPPLTDL LNGLKMGRFE RGLSSFQQSV AMDRIQRIVG VLQKPQMGER YLGTLLQVEG MLKTWFPQ
Antigen sequence identity:
- Mouse: 97%
- Rat: 95%
Target Information
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors CRY1, CRY2, and BHLHE41. In a histone deacetylase-dependent manner, represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes.
Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1.
Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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