Thermo Fisher Scientific POLR3C Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
QHFRDQAIVS AVANRMDQTS SEIVRTMLRM SEITTSSSAP FTQPLSSNEI FRSLPVGYNI SKQVLDQYLT LLADDPLEFV GKSG

Highest antigen sequence identity to the following orthologs:

• Mouse: 96%
• Rat: 95%

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
POLR3C may interact with other members of the RNA Pol III subcomplex to bind the TFIIIB-DNA complex via interactions between TFIIIB and POLR3F.
It may be involved in recruitment and stabilization of the subcomplex within RNA polymerase III or in stimulating catalytic functions of other subunits during initiation.
POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It acts as a nuclear and cytosolic DNA sensor involved in the innate immune response, recognizing non-self dsDNA that serves as a template for transcription into dsRNA.
Non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.