Thermo Fisher Scientific CD45RB (B-Cell Marker) Monoclonal Antibody (PD7/26)
CD45RB 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능합니다. Protein A/G 정제, PBS buffer에 보존되며, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC-PFA) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PD7/26 |
| Immunogen | Human peripheral blood lymphocytes maintained in T cell growth factor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. It promotes cell survival by modulating integrin-mediated signal transduction pathways and is involved in DNA fragmentation during apoptosis.
CD45 isoforms differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. Their expression depends on cell type and physiological state. CD45RB is expressed in microglia and inflammatory cells.
CD45 is expressed on cells of the human hematopoietic lineage except mature red cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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