Thermo Fisher Scientific RET Monoclonal Antibody (1C6)
RET 단백질을 표적으로 하는 Mouse IgG2a 모노클로날 항체로, 인간 시료에 반응합니다. ELISA에 1 ng/mL로 검증되었으며, GST 태그 결합 재조합 단백질을 면역원으로 사용했습니다. 액상 형태로 제공되며, PBS(pH 7.4)에 보존제 없이 -20°C에서 보관합니다.
- 카탈로그번호
- H00005979-M07
- 판매단위
- pk
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Applications
- ELISA (ELISA)
- Tested Dilution: 1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C6 |
| Immunogen | RET (AAH03072, 361 a.a. ~ 458 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV SLHLPSTYSL SVSRRARRFA QIGKVCVENC LADLTGDAVS GRDEARSSGL GSQKHPGS
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene, with additional variants described but not biologically confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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