Thermo Fisher Scientific Perforin-1 (Pore Forming Protein) Monoclonal Antibody (PRF1, 2467)
인간 Perforin-1 단백질을 인식하는 마우스 단클론 항체로, ELISA 및 Peptide Array에 사용 가능. 단백질 A/G로 정제된 액상형 항체이며, 보존제 무첨가 PBS 용액에 1 mg/mL 농도로 제공. 세포독성 림프구 연구 및 면역방어 기전 분석에 적합.
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- 5551-MSM1-P1ABX
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PRF1, 2467 |
| Immunogen | Recombinant human Perforin-1 protein fragment (around aa 413–552) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- This antibody has only been tested in direct ELISA.
Target Information
Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored in and released by cytoplasmic granules. Perforin plays a crucial role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin is a 555 amino acid protein with a 21 amino acid signal peptide and has a molecular weight of approximately 70–75 kDa. It is a pore-forming protein with a mechanism of transmembrane channel formation similar to complement component C9, and homology between perforin and C9 has been demonstrated.
Studies show that perforin is expressed only in killer cell lines, not in helper T lymphocytes or other tumor cells. It is a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Mutations in the perforin gene are associated with familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare, lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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