Thermo Fisher Scientific MMP-15 Polyclonal Antibody
MMP-15 단백질 검출용 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot과 IHC(P) 적용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 안정적인 PBS 버퍼에 보관.
- 카탈로그번호
- 500-4124
- 판매단위
- pk
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Thermo Fisher Scientific MMP-15 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Matrix MMP-15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human liver
- Cellular location: Secreted, extracellular space, extracellular matrix.
Target Information
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of the matrix metalloproteinase family, ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, and MT3-MMP (also known as MMP14, MMP15, MMP16 respectively) contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMP in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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