Thermo Fisher Scientific ATG5 Polyclonal Antibody
ATG5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 자가포식 및 세포사멸 관련 연구에 활용 가능. 합성 펩타이드 항원을 사용해 제작된 비결합 항체로, 장기 안정성을 위해 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse ATG5 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1089696 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute with 150 µL of distilled water.
Target Information
ATG5 (Autophagy Related 5) is a key component of the autophagy process and plays a role in apoptosis. It participates in mitochondrial quality control, antiviral immune regulation, lymphocyte development, MHC II antigen presentation, and adipocyte differentiation. Upon conjugation with ATG12, ATG5 contributes to autophagosome formation and autophagic cell death through interaction with FADD. The ATG5-ATG12 complex forms a cup-shaped isolation membrane that detaches after autophagosome completion. It also interacts with innate immune proteins such as RIG-I and VISA, inhibiting type I interferon production and enabling viral replication. ATG5 dysfunction is associated with spinocerebellar ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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