Thermo Fisher Scientific Human KappaB ras1 Synthetic Peptide
Human KappaB ras1 합성 펩타이드로, PA5-20340 항체의 블로킹 펩타이드로 사용 가능. 인간 유래 단백질 반응성, 액상 형태, 고순도 정제 제품. 연구용으로 NF-kappa-B 관련 단백질 연구에 적합.
- 카탈로그번호
- PEP0460
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human KappaB ras-1.
PEP-0460 can be used as a blocking peptide with polyclonal antibody PA5-20340.
Target Information
KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins similar to Ras-like small GTPases that associate with Ikappa-B, an inhibitor of the transcription factor NF-kappa-B.
Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain.
While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm.
It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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