Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunohistochemistry에 적합. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품이며 PBS에 0.02% sodium azide 함유. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human DRAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155232 |
Product Specific Information
- Suggested positive control: 293 cell lysate
- PA5-20335 can be used with blocking peptide PEP-0455
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers suggests autophagy may play a significant role in cancer progression. At least two isoforms of DRAM are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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