Thermo Fisher Scientific GRP78 Polyclonal Antibody
Thermo Fisher Scientific의 GRP78 Polyclonal Antibody는 ER 내 단백질 접힘 및 스트레스 반응 연구에 적합합니다. Western Blot, IHC, ICC 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 6 publications |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1–5 µg/mL | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Published Species | Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from residues 600 to the C-terminus of Mouse GRP78 BiP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978031 |
Product Specific Information
- For Western Blot, non-specific bands may appear at 100 kDa.
- Heat-mediated antigen retrieval is recommended prior to tissue staining.
- Store antibody at 4°C for 1–2 weeks; for long-term storage, keep at -20°C.
Target Information
GRP78 is a 78 kDa glucose-regulated protein belonging to the HSP70 family. It resides in the endoplasmic reticulum (ER) and transiently associates with newly synthesized secretory and membrane proteins. GRP78 interacts with mutant and misfolded proteins, marking them for degradation. The conserved KDEL sequence at its C-terminus ensures ER retention via the KDEL receptor.
GRP78 plays a key role in protein folding, degradation of misfolded proteins, and maintenance of cell homeostasis. It prevents apoptosis and serves as a biomarker of hypoglycemia. GRP78 provides neuroprotective functions under oxidative stress and glutamate exposure. Reduced GRP78 levels are observed in Alzheimer’s Disease brains and in PS1 gene mutations. Induction of GRP78 is associated with antitumor drug resistance.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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