Thermo Fisher Scientific Cdc42GAP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells.
It functions as a GTPase-activating protein (GAP) for Rho and Rac family proteins, which regulate cytoskeletal actin and membrane ruffling.
The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP.
The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.