Thermo Fisher Scientific Calmodulin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

Calmodulin mediates the control of numerous enzymes, ion channels, aquaporins, and other proteins by Ca²⁺. The calmodulin–Ca²⁺ complex stimulates various protein kinases and phosphatases. Together with CCP110 and centrin, it participates in regulating the centrosome cycle and cytokinesis.
Calmodulin is a small, highly conserved calcium-binding protein found in all eukaryotic cells. It binds up to four calcium ions and acts as an intracellular receptor for regulatory calcium signals.
Upon calcium binding, calmodulin undergoes conformational changes that enhance its affinity for target proteins. It functions both directly and indirectly through kinases and is involved in processes such as energy metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of cAMP and calcium levels.
Calmodulin contains 149 amino acids and four calcium-binding domains, playing key roles in growth, cell cycle regulation, signal transduction, and neurotransmitter synthesis and release.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(원본에 명시된 항원 이미지: PA5-86525_Calmodulin_P0DP23-1_Rabbit.svg / PA5-86525_Calmodulin_P0DP23-1_Rabbit_PDP.jpeg)