Thermo Fisher Scientific KLF10 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:10,000

ChIP Assay (ChIP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa nuclear, eGFP-human KLF10-transfected 293T
• Predicted reactivity: Rhesus Monkey (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation. It may inhibit Smad7 expression in bronchial epithelial cells and is ubiquitously expressed across tissues. Overexpression has been associated with renal clear cell carcinoma and other tumors. Defects in the related gene KLF11 are linked to maturity-onset diabetes of the young type 7 (MODY7).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.