Thermo Fisher Scientific LNX1 Polyclonal Antibody
LNX1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, 1.06 mg/mL 농도의 액상 형태로 제공됩니다. 인간 유래 단백질에 반응하며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 501–594 of human LNX1 (NP_0011198001) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806585 |
Product Specific Information
Immunogen sequence:
ITCHEKVVNI QKDPGESLGM TVAGGASHRE WDLPIYVISV EPGGVISRDG RIKTGDILLN VDGVELTEVS RSEAVALLKR TSSSIVLKAL EVKE
Target Information
Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is also known as PDZRN2 (PDZ domain-containing RING finger 2). Through its RING finger and PDZ domains, Lnx1 forms oligomers and interacts with target proteins such as JAM4 to create multiprotein complexes. Lnx1 functions as an E3 ubiquitin ligase containing NPXY motifs that bind to the Phosphotyrosine Binding (PTB) domain on Numb protein. This interaction mediates ubiquitination of Numb, preventing proteasomal degradation of the Notch intracellular domain (NICD) and positively regulating the Notch signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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