Thermo Fisher Scientific YAP1 Polyclonal Antibody
YAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 적합. 인간에 반응하며 Hippo 신호 경로 연구에 유용. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of Human Yes-associated protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with X. laevis, X. tropicalis, and Dog
Target Information
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, functioning as a transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP serves as a coactivator and corepressor and is a critical downstream regulatory target in the Hippo signaling pathway, which controls organ size and tumor suppression by restricting proliferation and promoting apoptosis. It also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and migration. Mutations in the IRF5 gene result in coloboma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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