Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa
• Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (93%), Pig (98%), Chicken (94%), Rhesus Monkey (100%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into mechanical energy of movement.
Cytoplasmic or axonemal Dynein heavy, intermediate, light, and light-intermediate chains are components of minus end-directed motors, transporting cellular cargos toward the cell center.
Axonemal Dynein motors contain one to three non-identical heavy chains and cause sliding of microtubules in the axonemes of cilia and flagella, enabling ciliary motion.
Cytoplasmic Dynein is a ~12 subunit complex including two heavy chains, two intermediate chains anchoring Dynein to cargo, four smaller intermediate chains, and several light chains.
It is essential for organelle transport, centrosome assembly, and other cellular functions.
The carboxy-terminus is conserved for microtubule-dependent motility, while the amino-terminal regions are variable.
Dynein activity is regulated by proteins such as Dynactin, LIS1, and nudel (nudE-like).

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.