Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), PE-Cyanine5.5

Applications

• Flow Cytometry (Flow)

Tested Dilution: Assay-dependent
Publications: View 4 publications

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential for T cell signal transduction, differentiation, and activation. It is expressed mainly on T cells as a CD8α/CD8β heterodimer, functioning as a co-receptor with TCR for MHC-I molecules. CD8α also forms homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes activates Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are critical for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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