Thermo Fisher Scientific Aldo-keto Reductase Family 1 Member C2/DD2 Monoclonal Antibody (CPTC-AKR1C2-1)
인간 AKR1C2/DD2 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체입니다. Western blot, IHC, Peptide Array 등 다양한 응용에 적합하며, Protein A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-AKR1C2-1 |
| Immunogen | Recombinant human full-length AKR1C2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed), incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
DD1 is also designated AKR1C1, DDH, or DDH1, while DD2 can be designated AKR1C2, dDD, BABP, or DDH2.
AKR1C3 and 3α-HSD are alternate designations for human DD3 (AKR1C18 in rodents), and DD4 can be called AKR1C4, CD, CHDR, or AKR1C6 (in rodents).
DD1 and DD2 are 20α-HSDs, whereas DD3 and DD4 are 3α-HSDs.
Human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, including polycyclic aromatic hydrocarbons, pesticides, and steroid hormones.
They catalyze the reduction of ketone-containing drugs using NADH or NADPH as cofactors.
20α-HSD converts progesterone to the inactive form, 20α-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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