Thermo Fisher Scientific PCAF Monoclonal Antibody (7D12C8)
PCAF 단백질을 표적으로 하는 마우스 단일클론 항체로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합합니다. 고순도 Protein G 정제, PBS 버퍼 및 sodium azide 함유. 인체 및 설치류 반응성. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7D12C8 |
| Immunogen | Purified recombinant fragment of human KAT2B (aa 1–142) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898459 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) that promotes transcriptional activation. It acetylates core histones (H3 and H4) and nucleosome core particles, as well as non-histone proteins such as ACLY, PLK4, and TBX5. PCAF inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. It also acts as a circadian transcriptional coactivator enhancing NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Additionally, it is involved in heart and limb development through acetylation of TBX5 and regulation of its nucleocytoplasmic shuttling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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