Thermo Fisher Scientific NME7 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:3,000

Product Specifications

Product Specific Information

• Positive Control: human embryonic stem cell, human LUC shRNA-transfected human embryonic stem cells, human NME7-1 shRNA-transfected human embryonic stem cells
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Protein kinases are enzymes that transfer a phosphate group from a donor molecule, typically the γ-phosphate of ATP, to an acceptor amino acid residue in a substrate protein. Through this mechanism, protein kinases mediate signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family comprises over 500 gene products and is classified into eight major groups based on sequence similarity of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
The STE group (homologs of yeast Sterile 7, 11, 20 kinases) includes 50 kinases related to the MAPK cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs), are well characterized in the yeast pheromone response pathway, where pheromones bind to Ste cell surface receptors to activate the MAPK pathway.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.