Thermo Fisher Scientific Synaptotagmin 1/2 Polyclonal Antibody
Rabbit Polyclonal Antibody targeting Synaptotagmin 1/2, reactive with human, mouse, and rat. Suitable for WB, IHC(PFA), and ICC/IF applications. Detects endogenous levels of total Synaptotagmin 1/2. Supplied as liquid, affinity purified, stored at -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SYT1 (Accession P21579), corresponding to amino acid residues G176–V226 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900628 |
Product Specific Information
Antibody detects endogenous levels of total Synaptotagmin 1/2.
Target Information
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that regulate both exocytosis and endocytosis, playing a key role in neurotransmitter secretion from small secretory vesicles.
Calcium binding to Synaptotagmin I triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1, regulating calcium-dependent interactions. Synaptotamin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, with highest mRNA levels in the hippocampus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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