Thermo Fisher Scientific PADI2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PADI2, suitable for WB, IHC, and ICC applications. Detects endogenous PADI2 levels. Affinity purified, liquid form, 1 mg/mL concentration. Stored at -20°C in PBS with glycerol and sodium azide.
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- PA5106273
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Thermo Fisher Scientific PADI2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PADI2 (Accession Q9Y2J8), corresponding to amino acid residues S495–Q545 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853950 |
Product Specific Information
Antibody detects endogenous levels of total PADI2.
Target Information
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. Family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates include myelin basic protein (CNS) and vimentin (skeletal muscle, macrophages). This enzyme is associated with neurodegenerative disorders such as Alzheimer’s disease and multiple sclerosis, and may be involved in glaucoma pathogenesis. The gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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