Thermo Fisher Scientific Caspase 1 Polyclonal Antibody
Rabbit polyclonal antibody against human Caspase-1. Validated for IHC, ICC/IF, and Flow Cytometry. Recognizes synthetic peptide within aa 162–205. Supplied as liquid, 1 mg/mL, purified by antigen affinity chromatography. For research use only.
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- PA5140994
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human Caspase-1 (aa 162–205) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932446 |
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases are primarily involved in immune responses to microbial pathogens rather than cell death. Members of this subfamily include caspase-1, -4, -5, and -12, which can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was first identified as an IL-1β–converting enzyme and later recognized as a mammalian homolog of the C. elegans cell death gene ced-3, capable of inducing apoptosis in fibroblasts when overexpressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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