Thermo Fisher Scientific Phospho-MST1R (Tyr1353) Polyclonal Antibody
Phospho-MST1R (Tyr1353) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. 다양한 면역분석(WB, IHC, ICC, Flow, ELISA)에 사용 가능. KLH 결합 인산화 펩타이드 면역원 기반, Protein A 정제, 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1353 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer resulting from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding induces tyrosine phosphorylation of the beta chain.
Knockout studies show that MST1R/RON (-/-) mice fail to survive past the periimplantation period. The MST1R/RON gene is mapped to 3p21, a region frequently deleted or mutated in small cell lung and renal carcinoma, and is implicated in several epithelial cancers. MST1R/RON expression occurs in many normal human tissues, with ESTs isolated from normal and cancerous colon, prostate, stomach, mouth, testis, and uterus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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