Thermo Fisher Scientific JAML Polyclonal Antibody

Thermo Fisher Scientific JAML Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  VCATILLLPV LILIVKKTCG NKSSVNSTVL VKNTKKTNPE MKEKPCHFER
• For short-term use, store at 2–8°C up to 1 week.
• For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology: Human 100%

Target Information

AMICA transmembrane protein of the plasma membrane of leukocytes controls their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells.
The interaction between both receptors mediates activation of gamma-delta T-cells, which are involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream signaling events through PI3-kinase and MAP kinases, resulting in proliferation and production of cytokines and growth factors by T-cells, stimulating epithelial tissue repair.
It also regulates leukocyte transmigration within epithelial and endothelial tissues through adhesive interactions with CXADR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음, OCR 텍스트 통합 완료)