Thermo Fisher Scientific SREBP1 (Transcription Factor) Monoclonal Antibody (SREBP1/1578)
SREBP1 단백질을 인식하는 Mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC(P) 및 IHC(PFA) 실험에 최적화되어 있으며, Protein A/G 정제 및 PBS buffer로 제공됩니다. 지방 및 콜레스테롤 대사 관련 연구에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SREBP1/1578 |
| Immunogen | Recombinant full-length human SREBP1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins. Three isoforms (SREBP-1a, SREBP-1c, and SREBP-2) have been identified in mammalian tissues, differing in structure, regulation, and function.
SREBPs exist as 120 kDa inactive precursors in the endoplasmic reticulum membrane. Upon activation, they translocate to the Golgi, undergo proteolytic cleavage, and form mature transcriptionally active fragments (60–78 kDa).
In liver and adipose tissues, SREBPs regulate lipid and cholesterol accumulation by inducing genes involved in these metabolic processes. SREBP-1 primarily regulates triglyceride synthesis, whereas SREBP-2 is more closely linked to cholesterol synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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