Thermo Fisher Scientific SREBP1 (Transcription Factor) Monoclonal Antibody (SREBP1/1578)
SREBP1 전사인자에 특이적인 Mouse Monoclonal Antibody로, 인간 시료에 반응합니다. IHC(P), IHC(PFA) 등 다양한 응용에 사용 가능하며, 단백질 A/G로 정제된 액상 형태입니다. 4°C 보관, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SREBP1/1578 |
| Immunogen | Recombinant full-length human SREBP1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins. Three isoforms have been identified in mammalian tissues, differing in structure, regulation, and function.
SREBP-1a and SREBP-1c (originally cloned as ADD1) are products of alternative promoter usage of the SREBP-1 gene, while SREBP-2 is transcribed from a different gene.
SREBPs exist as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, SREBPs translocate to the Golgi, where proteolytic cleavage produces a mature, transcriptionally active 60–78 kDa fragment.
In liver and adipose tissues, SREBPs regulate lipid and cholesterol metabolism by inducing genes involved in these processes. SREBP-1 primarily governs triglyceride synthesis and accumulation, whereas SREBP-2 is more closely linked to cholesterol synthesis and accumulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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