Thermo Fisher Scientific U2AF1L4 Polyclonal Antibody

Applications

• Western Blot (WB): 0.1–0.3 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with canine, mouse, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

RNA-binding protein functioning as a pre-mRNA splicing factor. Plays a critical role in constitutive and enhancer-dependent splicing by mediating protein–protein and protein–RNA interactions required for accurate 3′-splice site selection. Enhances U2AF2 binding to weak pyrimidine tracts and participates in alternative pre-mRNA splicing regulation. Activates exon 5 skipping of PTPRC during T-cell activation, an event reversed by GFI1. Binds RNA at the AG dinucleotide at the 3′-splice site, showing preference for AGC or AGA. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.