Thermo Fisher Scientific ASGR1 Polyclonal Antibody
ASGR1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 면역세포화학에 적합하며 인간과 마우스에 반응. 항원 친화 크로마토그래피로 정제, 액상 형태로 제공. 간세포 표면 수용체 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 25–291 of Human ASGPR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549503 |
Product Specific Information
- Recommended positive controls: Huh-7, HepG2, mouse liver
- Predicted reactivity: Rat (80%), Pig (84%), Bovine (82%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
The asialoglycoprotein receptor (ASGPR) is a 42 kDa transmembrane glycoprotein that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues. It is expressed on hepatocyte surfaces, predominantly on the sinusoidal and lateral plasma membranes, but not on the bile canalicular membrane. ASGPR facilitates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR comprises three subunits: rat hepatic lectin (RHL)-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and cross-reacts with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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