Thermo Fisher Scientific Cyclophilin A Polyclonal Antibody
Cyclophilin A 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS 용액 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 5–10 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Mouse Cyclophilin A/Ppia |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2902778 |
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to immunosuppressant agents such as cyclosporin A (CsA) or FK506. Proteins that bind FK506 are called FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent phosphatase involved in T-cell activation, explaining their immunosuppressive mechanism.
Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase), catalyzing protein folding steps. Within the cyclophilin family, CyPA (also known as CyP-18) is the most abundant and ubiquitous form, present in all vertebrate tissues including T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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