Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody

Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents—cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBPs), and those which bind cyclosporin A are called cyclophilins (CyPs). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase implicated in T-cell activation. This provides a possible mechanism of immunosuppression by CsA and FK506.

Immunophilins function as peptidyl prolyl cis-trans isomerases (PPIases), whose activity is inhibited by their respective immunosuppressant compounds. As PPIases, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.