Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody
Cyclophilin B 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 인간 시료 반응성을 보입니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용으로 사용됩니다.
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Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human Cyclophilin B fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902779 |
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents—cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBPs), and those which bind cyclosporin A are called cyclophilins (CyPs). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase implicated in T-cell activation. This provides a possible mechanism of immunosuppression by CsA and FK506.
Immunophilins function as peptidyl prolyl cis-trans isomerases (PPIases), whose activity is inhibited by their respective immunosuppressant compounds. As PPIases, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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