
Thermo Fisher Scientific Alpha Sarcoglycan Polyclonal Antibody
Alpha Sarcoglycan 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot 및 IHC(Paraffin) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SGCA (Product #RP-90085) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2647206 |
Product Specific Information
- Immunogen sequence:
SALDRGGRVP LPIEGRKEGV YIKVGSASPF STCLKMVASP DSHARCAQGQ PPLLSCYDTL APHFRVDWCN VTLVDKSVPE PADEVPTPGD GILEHDPFFC PPTEAPDRDF LVD - Highest antigen sequence identity to orthologs:
- Mouse: 95%
- Rat: 94%
Target Information
Sarcoglycan transmembrane proteins are members of the dystrophin complex. These proteins form a complex localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. The alpha-, beta-, gamma-, and delta-sarcoglycan subunits form a complex on the muscle cell surface membrane. Genetic defects in any of these proteins lead to loss or reduction of the entire sarcoglycan complex, causing autosomal recessive muscular dystrophy known as sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans associate with epsilon-sarcoglycan, homologous to alpha-sarcoglycan. Complete deficiency in delta-sarcoglycan results in Syrian hamster BIO.14 cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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