Thermo Fisher Scientific Alpha Sarcoglycan Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

• Immunogen sequence:
  SALDRGGRVP LPIEGRKEGV YIKVGSASPF STCLKMVASP DSHARCAQGQ PPLLSCYDTL APHFRVDWCN VTLVDKSVPE PADEVPTPGD GILEHDPFFC PPTEAPDRDF LVD
• Highest antigen sequence identity to orthologs:
  • Mouse: 95%
  • Rat: 94%

Target Information

Sarcoglycan transmembrane proteins are members of the dystrophin complex. These proteins form a complex localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. The alpha-, beta-, gamma-, and delta-sarcoglycan subunits form a complex on the muscle cell surface membrane. Genetic defects in any of these proteins lead to loss or reduction of the entire sarcoglycan complex, causing autosomal recessive muscular dystrophy known as sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans associate with epsilon-sarcoglycan, homologous to alpha-sarcoglycan. Complete deficiency in delta-sarcoglycan results in Syrian hamster BIO.14 cardiomyopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.