Thermo Fisher Scientific CKMT1A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Mouse heart, Rat heart, Rat testis
• Immunogen sequence:
  FLIWVNEEDH TRVISMEKGG NMKRVFERFC RGLKEVERLI QERGWEFMWN ERLGYILTCP SNLGTGLRAG VHIKLPLLSK DSRFPKILEN LRLQKRGTGG VDTAATGGVF DISNLDRLGK SEVELVQLVI DGVNYLIDCE RRLERGQDIR IPTPVIHTKH

Target Information

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes.
Mitochondrial creatine kinase occurs in two different oligomeric forms—dimers and octamers—in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes.
Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, which may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.