Thermo Fisher Scientific MRCK beta Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal 항체로 Western Blot 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- PA554613
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MRCK beta (Product #RP-88988) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644098 |
Product Specific Information
Immunogen sequence:
KSKFSGAVLN VPDTSDNSKK QMLRTRSKRR FVFKVPEEER LQQRREMLRD PELRSKMISN PTNFNHVAHM GPGDGMQVLM DLPLSAVPPS QEERPGPAPT NLARQPPSRN KPYISWPSSG GSEPSVTVPL RSMSDPDQDF DKEPDSDST
- Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 91%
Target Information
CDC42BPB is a serine/threonine kinase involved in actin cytoskeleton assembly and organization.
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK-alpha, MRCK-beta) contain a cysteine-rich motif and a pleckstrin homology domain.
MRCKs phosphorylate nonmuscle Myosin light chain and influence Actin-Myosin contractility.
MRCK-alpha can phosphorylate and activate LIM kinases downstream of Cdc42, leading to inactivation of ADF/Cofilin and actin cytoskeletal reorganization.
Additionally, MRCK-alpha can influence neurite outgrowth promoted by Cdc42 and Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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