Thermo Fisher Scientific CD2 Monoclonal Antibody (RPA-2.10), Functional Grade, eBioscience
인간 CD2를 인식하는 RPA-2.10 단클론 항체로, T세포 및 NK세포 표면 분석에 적합합니다. Flow cytometry 및 기능적 차단 실험에 사용 가능하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 4°C 보관, 저내독소 수준 보장.
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- 16-0029-xxx (5개 옵션)
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카탈로그
5개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD2 Monoclonal Antibody (RPA-2.10), Functional Grade, eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | 1 publication |
| Neutralization (Neu) | Assay-Dependent | 1 publication |
| Functional Assay | Assay-Dependent | - |
| Inhibition Assays (IA) | - | 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RPA-2.10 |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2865567 |
Available Conjugate Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- NovaFluor Blue 510
- NovaFluor Blue 585
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Yellow 570
- PE
- PE-Cyanine5
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 702
- Super Bright 780
- Custom conjugation available upon request
Product Specific Information
The RPA-2.10 monoclonal antibody reacts with human CD2, a 50 kDa cell surface receptor expressed on most thymocytes, all mature T cells, and subsets of NK cells. CD2 binds to CD58 and plays a role in T-cell adhesion and activation. RPA-2.10 blocks mixed lymphocyte reactions and cross-reacts with non-human primates and pigs.
Applications Reported:
- Flow cytometric analysis
- Blocking of CD2 activity in in vitro functional assays
Applications Tested:
Validated by flow cytometric analysis of normal human peripheral blood cells. Recommended ≤ 0.5 µg per test in 100 µL final volume. Optimal titration is advised.
Storage and Handling:
Use in a sterile environment.
Filtered post-manufacture (0.2 µm).
Purity and Quality:
- Purity: >90% (SDS-PAGE)
- Endotoxin: <0.001 ng/µg antibody (LAL assay)
- Aggregation: <10% (HPLC)
Target Information
CD2 (LFA-2) is a monomeric surface antigen (45–58 kDa) expressed on all peripheral blood T cells and some NK cells but not on B lymphocytes. It is among the earliest T-cell markers, present on >95% of thymocytes. CD2 interacts with CD58 to mediate adhesion between T cells and antigen-presenting cells. T-cell activation increases CD2 expression and mobility, enhancing CD58-CD2 contact and adhesion. CD2 deficiency is associated with reduced intestinal inflammation and immune dysfunction. Related diseases include penile squamous cell carcinoma and thymus-absence-related immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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