Thermo Fisher Scientific RHOA Polyclonal Antibody
RHOA 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 등 다양한 종에 반응하며, PBS 및 글리세롤 기반 용액으로 안정화되어 있습니다. 세포 골격 및 신호전달 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RHOA (Accession P61586), corresponding to amino acid residues T163–L193 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818470 |
Product Specific Information
This antibody detects endogenous levels of total RhoA.
Target Information
RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. It participates in microtubule-dependent signaling required for myosin contractile ring formation during cytokinesis and is essential for cleavage furrow formation.
RhoA is also required for apical junction formation in keratinocyte cell-cell adhesion and acts as a target for yopT cysteine peptidase from Yersinia pestis and Yersinia pseudotuberculosis.
It stimulates PKN2 kinase activity, may activate PLCE1, and is activated by ARHGEF2, which promotes GDP-GTP exchange.
RhoA is essential for SPATA13-mediated regulation of cell migration and adhesion dynamics. The MEMO1–RHOA–DIAPH1 signaling pathway plays a key role in ERBB2-dependent microtubule stabilization at the cell cortex, controlling APC and CLASP2 localization via GSK3B regulation. Membrane-bound APC recruits MACF1 for microtubule capture and stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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