Thermo Fisher Scientific Wilm`s Tumor 1 (WT1) (Wilm`s Tumor and Mesothelial Marker) Polyclonal Antibody
WT1 단백질을 인식하는 토끼 폴리클로날 항체로, 인간 및 랫트 시료에 반응합니다. 파라핀 또는 PFA 고정 조직의 면역조직화학(IHC)에 적합하며, 단백질 A/G 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant human WT1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Wilms Tumor 1 (WT1) gene encodes a WPP domain-interacting protein required for RanGAP nuclear envelope association in root tip cells. Ran GTPase is essential for nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic RanGAP protein helps maintain the RanGTP/RanGDP gradient across the nuclear envelope and associates with its outer surface in metazoan and plant cells.
In Arabidopsis thaliana, RanGAP association with the nuclear envelope requires nucleoporins containing coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WT1 and WIT2 represent a second CC-TMD protein family distinct from WIPs, essential for RanGAP nuclear envelope association in root tip cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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