Thermo Fisher Scientific ATP1A3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Product Specifications

Product Specific Information

• Immunogen sequence: EVAMTEHKMS VEEVCRKYNT DCVQGLTHSK AQE

Target Information

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA).

The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit (alpha subunit) and an associated smaller glycoprotein (beta subunit). There are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2), encoded by multigene families. The different isoforms exhibit tissue-specific and developmental expression patterns. The alpha-3 subunit is found in neuronal, skeletal, cardiac muscle, lung, and stomach tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.