Thermo Fisher Scientific FGFR3 Monoclonal Antibody (2H10B4)
FGFR3 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB, IHC, Flow, ELISA 등 다양한 응용에 적합. 고순도 Protein G 정제, 1 mg/mL 농도, PBS buffer 및 sodium azide 포함. 인간 FGFR3에 특이적이며 연구용으로 사용.
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Thermo Fisher Scientific FGFR3 Monoclonal Antibody (2H10B4)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H10B4 |
| Immunogen | Purified recombinant fragment of human FGFR3 (aa 529–694) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898434 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
FGFR3 (Fibroblast Growth Factor Receptor 3) is a receptor tyrosine kinase belonging to the FGFR family. These receptors regulate cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair. FGFR family members differ in ligand affinities and tissue distribution. FGFR3 interacts with fibroblast growth factors to trigger downstream signaling, influencing mitogenesis and differentiation. It plays a crucial role in bone development and maintenance. Mutations in FGFR3 are associated with craniosynostosis and various skeletal dysplasias. Multiple alternatively spliced transcript variants produce different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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