Thermo Fisher Scientific PrP Polyclonal Antibody
PrP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(P)에서 사용 가능하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제된 동결건조 형태로 제공. 연구용 전용.
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Applications
- Western Blot (WB): 0.1–0.5 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): 0.5–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human PRNP recombinant protein (Position: S143–S230) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746993 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functioning as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes.
Conversion of normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step triggering prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD).
While PrPc is rich in alpha-helices, the PrPSc form contains more beta-sheets and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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