Thermo Fisher Scientific Lass6 Polyclonal Antibody

Thermo Fisher Scientific Lass6 Polyclonal Antibody

제품 사양

Product Specific Information

Immunogen sequence:
SSSDEEDSEP PGKNPHTATT TNGTSGTNGY LLTGSCSMDD

Target Information

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation.
May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1.
Localized to nuclear membrane as a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane.
Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contains a homeodomain and LAG1 domain.
Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a large genomic region of 318 kb.
Sequences in mouse and zebrafish suggest conservation of LASS6 in vertebrates because the protein and genomic sequences are highly conserved.
LASS6 is broadly expressed in a wide range of tissues. Recent data suggest a role in cancer differentiation and early embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.