Thermo Fisher Scientific TRPM2 Polyclonal Antibody
TRPM2 단백질을 표적하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin)에 적합. 인간 및 랫트 반응성 확인. 항원 친화 크로마토그래피로 정제되었으며, 고농도 액상 형태로 제공. 산화 스트레스 및 칼슘 이온 채널 연구에 활용 가능.
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Thermo Fisher Scientific TRPM2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 181–423 of TRPM2 (Uniprot ID: O94759) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.38 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152374 |
Product Specific Information
- Recommended positive controls: HepG2, HepG2 membrane extract
- Predicted reactivity: Mouse (90%), Rat (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRPM2 belongs to the ion transport protein family, including sodium, potassium, and calcium ion channels. These proteins have six transmembrane helices, with the last two flanking a loop that determines ion selectivity.
TRPM2 is activated by oxidative stress and confers susceptibility to cell death. It functions as a calcium-permeable cation channel regulated by free intracellular ADP-ribose.
Several alternatively spliced transcript variants of the TRPM2 gene have been described, though their full-length nature remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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