Thermo Fisher Scientific CD2AP Polyclonal Antibody
CD2AP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–281 of Human CD2AP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.17 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545867 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, A375, Rat2, K562, THP-1, HL-60
- Predicted reactivity: Mouse (87%), Rat (86%), Pig (92%), Rhesus Monkey (96%), Bovine (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and various cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing SH3 domain binding sites. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is involved in dynamic actin remodeling and membrane trafficking during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is associated with susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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