Thermo Fisher Scientific PRDM2 Polyclonal Antibody
PRDM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat에 반응하며 Protein A로 정제된 고순도 항체. 암 연구 및 세포 분화 관련 연구용.
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Thermo Fisher Scientific PRDM2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PRDM2/RIZ1, amino acids 1301–1400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PRDM2 is a member of the nuclear/histone methyltransferase superfamily, containing an N-terminal PR domain, Rb-binding motif, eight Kruppel-like zinc finger motifs, a nuclear hormone-receptor binding motif, and a C-terminal PR-domain binding motif. It is expressed ubiquitously at low levels and exists in two isoforms:
- RIZ1 (280 kDa) with PR domain
- RIZ2 (250 kDa) lacking PR domain
PRDM2 acts as a tumor suppressor involved in cell growth and differentiation. It binds to Retinoblastoma protein, estrogen receptor, GATA-3, and TPA-responsive element (MTE) of the Heme-oxygenase-1 gene. It influences the pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, and estrogen action. Mutations and hypermethylation of PRDM2 are associated with various human cancers, suggesting its potential as a biomarker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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