Thermo Fisher Scientific TSLP Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
YDFTNCDFEK IKAAYLSTIS KDLITYMSGT KSTEFNNTVS CSNRPHCLTE IQSLTFNPTA GCASLAKEMF AMKTKAALAI WCPGYSETQI NATQAMKKRR KRKVTTNKCL EQVSQLQGLW RRFNRPLLKQ Q

Positive Samples: U-87MG, Rat brain

Target Information

TSLP is a 159 amino acid four-helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c(+) dendritic cells, naive CD4(+) and CD8(+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation.
TSLP influences the regulation of regulatory T cell selection and maintenance of peripheral CD4(+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in inflammatory arthritis. It is expressed in heart, liver, and prostate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.