Thermo Fisher Scientific FBXO33 Polyclonal Antibody
Human FBXO33 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FBXO33. Recombinant protein control fragment (Product #RP-102199) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641546 |
Product Specific Information
Immunogen sequence:
NNRNLQKFSL FGDISVLQQQ GSLSNTYLSK VDPDGKKIKQ IQQLFEEILS NSRQLKWLSC GFMLEIVTPT SLSSLSNAVA NTMEHLSLLD NNIPGNSTLI TAVELERFVN LHSLALDFCD FTAEMARVL
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
FBXO33 is the substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
FBXO33 probably recognizes and binds to phosphorylated target proteins and recognizes YBX1.
Members of the F-box protein family, such as FBXO33, are characterized by an approximately 40-amino acid F-box motif.
SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.
F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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