Thermo Fisher Scientific LGI1 Recombinant Rabbit Monoclonal Antibody (ARC2388)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC2388

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human LGI1 (O95970) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LGI1,uniProtId:O95970-1,ncbiNodeId:9606,antigenRange:150-250,antigenLength:557,antigenImageFileName:MA5-37868_LGI1_O95970-1_Rabbit.svg,antigenImageFileNamePDP:MA5-37868_LGI1_O95970-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.67 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897788

Product Specific Information

Positive Samples: Mouse brain, Rat brain

Immunogen sequence: NLQTLPKDIF KGLDSLTNVD LRGNSFNCDC KLKWLVEWLG HTNATVEDIY CEGPPEYKKR KINSLSSKDF DCIITEFAKS QDLPYQSLSI DTFSYLNDEY V

Target Information

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.